The deaths in a flat fire of a 21-year-old man and his eight-year-old sister are being treated as murder, Strathclyde Police have confirmed.
Their parents are seriously ill in hospital after suffering burns in the blaze at the property in Helensburgh.The man's body was discovered in the Scott Court building at about 0500 BST.
His sister died after she was taken to the Royal Alexandra Hospital in Paisley alongside her mother, 46, and father 55.
The injured man was later transferred to Glasgow Royal Infirmary.
Strathclyde Police said that an investigation was currently under way to establish the cause of the fire.
A mobile police incident room has been set up in the town, in Argyll and Bute.A police helicopter flew over the scene to take aerial pictures.
The police said extensive enquiries had been "on-going all day at the scene", including a "full crime scene forensic investigation" by forensic scientists, the fire service and Strathclyde Police.
Post mortem examinations will be carried out and a report has been forwarded to the procurator fiscal.
The officer in charge of the investigation, Detective Chief Inspector Anne McKerchar said: "This is a tragic event made worse by the fact that it was a deliberate act.
"I would appeal to anyone with any information that may help police enquiries to come forward.
"In particular, I would ask anyone who was in the James Street, West Princes Street or West Clyde Street areas of Helensburgh around 0500 hours this morning who may have seen anything suspicious or untoward to contact us as a matter of urgency."
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